Open AccessTransforming growth factor (TGF) – is it a key protein in mammalian reproductive biology?
Author(s) -
Marta Rybska,
Sandra Knap,
Katarzyna Stefańska,
Maurycy Jankowski,
Agata Chamier-Gliszczyńska,
Małgorzata Popis,
Michal Ješeta,
Dorota Bukowska,
Paweł Antosik,
Bartosz Kempisty,
J. M. Jaśkowski
Publication year - 2018
Publication title -
medical journal of cell biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.294
H-Index - 8
ISSN - 2544-3577
DOI - 10.2478/acb-2018-0020
Subject(s) - biology , bone morphogenetic protein , smad , microbiology and biotechnology , signal transduction , transforming growth factor beta , r smad , transforming growth factor , growth differentiation factor , endoglin , genetics , gene , stem cell , cd34
The superfamily of transforming growth factors β (TGF-β) consists of cytokines that are crucial in regulating the organism’s biological functions and includes three isoforms of TGF-β protein, Anti-Müllerian Hormone (AMH), inhibin A and B, activins, 20 bone morphogenetic proteins (BMP1-20) and 9 growth factors (GDF1-9). Their signal transduction pathway involves three types of membrane receptors that exhibit a serine/threonine kinase activity, as well as the Smad proteins. After ligand binding, the Smad proteins are phosphorylated and translocated to the nucleus, where they interact with transcription factors and affect gene expression. TGF-β family members are involved in cell growth and differentiation, as well as chemo-taxis and apoptosis, and play an important role during an inflammation. Defects in TGF-β proteins or in their signalling pathway underlie many severe diseases, such as systemic lupus, systemic scleroderma, bronchial asthma, atherosclerosis, hyperthyroidism or cancer. These factors are also crucial in mammal reproductive functions, as they are involved in folliculogenesis, steroidogenesis, ovulation, maternal-embryo interaction, embryo development and uterine decidualization. Their defects result in issues with fertility. This review focuses on the relevance of TGF-β family members in a mammal reproduction with an emphasis on three TGF-β isoforms, inhibins A and B, GDF-9 and their signal transduction pathway.