Open AccessImpact of QRS duration on left ventricular remodelling and survival in patients with heart failure
Author(s) -
Sam Straw,
Melanie McGinlay,
John Gierula,
Judith Lowry,
Maria F. Paton,
Charlotte Cole,
Michael Drozd,
Aaron Koshy,
Wilfried Mullens,
Richard M Cubbon,
Mark T. Kearney,
Klaus K. Witte
Publication year - 2021
Publication title -
journal of cardiovascular medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.458
H-Index - 47
eISSN - 1558-2035
pISSN - 1558-2027
DOI - 10.2459/jcm.0000000000001231
Subject(s) - medicine , ejection fraction , cardiology , qrs complex , cardiac resynchronization therapy , heart failure , diastole , cohort , blood pressure
In patients with chronic heart failure, QRS duration is a consistent predictor of poor outcomes. It has been suggested that for indicated patients, cardiac resynchronization therapy (CRT) could come sooner in the treatment algorithm, perhaps in parallel with the attainment of optimal guideline-directed medical therapy (GDMT). We aimed to investigate differences in left ventricular (LV) remodelling in those with narrow QRS (NQRS) compared with wide QRS (WQRS) in the absence of CRT, whether an early CRT strategy resulted in unnecessary implants and the effect of early CRT on outcomes.