Open AccessRB139, RB140, RB141 and RB142 antibodies recognize human citrullinated LL37 by ELISA
Author(s) -
Raffaella Palazzo,
Immacolata Pietraforte,
Carlo Chizzolini,
Roberto Lande,
Loredana Frasca
Publication year - 2020
Publication title -
antibody reports
Language(s) - English
Resource type - Journals
ISSN - 2624-8557
DOI - 10.24450/journals/abrep.2020.e189
Subject(s) - antibody , monoclonal antibody , immunology , medicine
LL37 is a natural antibiotic, active against bacteria and fungi and some viruses. Here we show that three monoclonal antibodies (RB139, RB141, and RB142) are exclusively specific for citrullinated LL37, whereas RB140 recognizes both native LL37 and cit-LL37. None recognizes LL37 modified by carbamylation. These antibodies can represent previously unavailable tools to detect the presence of citrullinated LL37 in body fluids by ELISA in the course of autoimmune and infectious diseases.