Open AccessSystemic Light Chain Amyloidosis (Congo Red Inconclusive) with Underlyng Clonal Expansion Not Meeting the Criteria of Light Chain Monoclonal Gammopathy of Renal Significance or Light Chain Myeloma:A Case Report
Author(s) -
Sanjay Kumar
Publication year - 2020
Publication title -
journal of advanced research in medicine
Language(s) - English
Resource type - Journals
eISSN - 2394-7047
pISSN - 2349-7181
DOI - 10.24321/2349.7181.202019
Subject(s) - immunoglobulin light chain , amyloidosis , multiple myeloma , medicine , monoclonal gammopathy of undetermined significance , nephrotic syndrome , al amyloidosis , bence jones protein , gammopathy , renal biopsy , paraproteinemias , monoclonal , congo red , pathology , bone marrow , biopsy , antibody , gastroenterology , monoclonal antibody , chemistry , immunology , organic chemistry , adsorption
Fifty-eight-year-old male admitted for evaluation of nephrotic syndrome and chronic diarrhoea was detected to have Immunoglobulin light chain amyloidosis (AL Amyloidosis) which was congo red inconclusive from renal biopsy. Bone marrow biopsy showed monoclonal plasma cells of 40% and light chain assay showed predominance of immunoglobulin lambda light chain. The diagnosis was neither fitting into the current diagnostic criteria for light chain Monoclonal Gammopathy of Renal Significance (MGRS) nor light chain myeloma. Literature is scarce regarding patients with AL amyloidosis having underlying clonal expansion not meeting the criteria of light chain myeloma or light chain MGRS.