Open AccessGlycemic Variation in Patients of Acute Coronary Syndrome with Hyperglycaemia and its Relationship with Oxidative Stress: A Pilot Study
Author(s) -
Kapil Kumar,
Pinki Kumari,
R Avasthi,
Rafat Ahmed,
Mohd Jaid,
Ravindra Kumar
Publication year - 2020
Publication title -
journal of advanced research in medicine
Language(s) - English
Resource type - Journals
eISSN - 2394-7047
pISSN - 2349-7181
DOI - 10.24321/2349.7181.202015
Subject(s) - glycemic , medicine , asymptomatic , oxidative stress , glycemic index , diabetes mellitus , cardiology , blood sugar , endocrinology , gastroenterology
Aim:The aim of this study was to establish the relationship between the glycemic variation in patients of Acute Coronary Syndrome (ACS) with hyperglycemia, oxidative stress and pre-discharge assessment of glycemic status by Oral Glucose Tolerance Test (OGTT). Materials and Method: Nineteen non-diabetic patients who presented with acute coronary syndrome with random blood sugar ≥200 mg/dl were recruited and glycemic variation was measured using CGMS followed by measurement of 8-isoprostanes PG-2alpha as a marker of oxidative stress, and pre-discharge OGTT was done to know the glycemic status at the time of discharge. Result: Mean MAGE (A parameter of glycemic variation) was 106.92±22.66 and mean 8-isoprostanes level was 206.05±179.57. There was no relationship between these two values. On doing OGTT, out of 19 non diabetic patients 11 turned out to be frank diabetic and 8 were having impaired glucose tolerance after OGTT, none were euglycemic. Conclusion:The study highlighted the issue of hyperglycaemia in ACS patients and their abnormal glucose tolerance in the short term, most of them turning to be frankly diabetic and being totally asymptomatic till the time of index event, although no correlation was found between glycemic variability and oxidative stress.