Ascorbic Acid as an Inhibitor for SARS-CoV-2 Virus Reproduction: A Theoretical Approach | Zendy

Mohammed Abed Jawad | Zendy

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Ascorbic Acid as an Inhibitor for SARS-CoV-2 Virus Reproduction: A Theoretical Approach

Author(s) -

Mohammed Abed Jawad

Publication year - 2021

Publication title -

journal of communicable diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.151

H-Index - 26

eISSN - 2581-351X

pISSN - 0019-5138

DOI - 10.24321/0019.5138.202155

Subject(s) - ascorbic acid , virus , viral replication , reproduction , vitamin c , antibody , virology , docking (animal) , biology , chemistry , biochemistry , veterinary medicine , genetics , food science , medicine

In the present study, ascorbic acid’s or Vitamin C’s influence (VC) in inhibition of SARS-CoV-2 virus reproduction was investigated. Gaussian 09 with a basis set of 6-311G (d, p), MGL tools, DSV, and LigPlus software were used. According to the Total Electron Density (TED) and Millikan charges, the active sites for adsorption were determined. Further, the docking study had clearly revealed the role of VC in inhibition of the virus reproduction in accordance with binding energy (Eb) and ligand efficiency (LE). The vitamin’s interaction with the virus’s spikes may limit its replication or provide the immune system sufficient time to recognize the infection, which enhances the possibility of producing appropriate antibodies.

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