Open AccessTrend of Antimicrobial Susceptibility Profile of Vibrio cholera Strains Isolated in Indian Children’s during 2008-2016
Author(s) -
Vikas Manchanda
Publication year - 2021
Publication title -
journal of communicable diseases/journal of communicable diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.151
H-Index - 26
eISSN - 2581-351X
pISSN - 0019-5138
DOI - 10.24321/0019.5138.202111
Subject(s) - vibrio cholerae , cholera , serotype , outbreak , antibiotic resistance , microbiology and biotechnology , antimicrobial , biology , veterinary medicine , epidemiology , el tor , medicine , virology , antibiotics , bacteria , genetics
Background: The unique epidemiologic attribute of the cholera is its propensity to occur as an outbreak that may flare- up into epidemics, if not controlled. The causative bacterial pathogen Vibrio cholerae prevails in the environment and infects humans whenever there is a breakdown in the public health component. The upsurge in antimicrobial resistance directly influences the management and spread of the disease. Objectives: The present study documents the epidemiological profile and the changing trends in antimicrobial resistance of eight years (2008-2016) in Vibrio cholerae isolates. Methodology: A retrospective study was undertaken with review of records of a period of eight years (January 2008 to December 2016) from two government hospitals in Delhi. All data were captured in WHONET and was analyzed. V. cholerae isolates were identified using standard microbiological techniques and were serotype using antisera. Antimicrobial susceptibility testing was performed using disc diffusion and Vitek-2 automated method. Result: During the period of eight years, 315 cases were confirmed microbiologically as cholera. A significant outbreak of cholera (88 cases) occurred in 2013 followed by sporadic cases in 2012 through 2016. Males outnumbered the females by Male to female ratio of 1:0.8. Mostly cases presented during the months of June to October. Almost all (92%) isolates were V. cholerae O1, biotype ElToR and serotype Ogawa. The antibiogram over the period of eight years showed that isolates were consistently sensitive to aminoglycosides. However, emerging resistance was seen to quinolones and β-Lactam group. Conclusion: The emergence of resistance amongst V. cholerae especially towards quinolones may significantly influence the control strategies in future outbreaks. Therefore, continuous surveillance with regards to drug resistance, as well as epidemiological variation is necessary for early detection. A strong regional commitment may help contain the disease.