Open AccessSerum Osteopontin Growth hormone , and Other Biochemical Parameters in Children with Acute Lymphoblastic Leukemia
Author(s) -
Atheer Awad Mehde,
Wesen Adel Mehdi,
Karima Fadhil Ali
Publication year - 2011
Publication title -
journal of advances in chemistry
Language(s) - English
Resource type - Journals
ISSN - 2321-807X
DOI - 10.24297/jac.v7i1.976
Subject(s) - osteopontin , medicine , cd44 , lymphoblast , white blood cell , leukemia , endocrinology , acute leukemia , lymphoblastic leukemia , immunology , biology , cell , cell culture , genetics
Acute lymphoblastic leukemia (ALL) is a custom of leukemia, or cancer of the white blood cells categorized by excess lymphoblasts and Chemotherapy is the initial treatment of choice. Most ALL patients will receive a combination of different treatments.Osteopontin (OPN) is a glycoprotein that cooperates with a variety of cell surface receptors, as well as several integrins and CD44. OPN is secreted by numerous human malignancies. We aimed to evaluate serum levels of osteopontin and growth hormone(GH) in patients with Acute lymphoblastic leukemia in childhood. We studied serum levels of OPN ,GH and other biochemical levels of 60 patients that diagnosis as acute lymphoblastic leukemia. The mean levels of OPN were significantly higher in patients (10.00± 1.15 ng/ml) than in control (7.62± 0.60 ng/ml). The mean levels of GH levels were significantly lower in patients (2.98± 0.51ng/dl) than in control (6.02± 1.00 ng/dl. The mean levels of the iron and total protein in ALL patients were (95.78± 10.11 µg/dl), (6.08 ± 1.16 g/dl)respectively. The present study showed a significant negative correlation between GH with osteopontin (OPN) ,while there a positive significant correlate between GH with hemoglobin in patients group compared to control group. The present study Conclude that elevated levels of osteopontin and decreased GH levels at the diagnosis may predict an unfavorable result in ALL childhood .