Open AccessSynthesis of some Heterocyclic compounds bearing Coumarin nucleus and their Anti-inflammatory activity
Author(s) -
Nadia Dawoud,
Nahed Abdel-Ghaffar,
Mona M Abdl-gali,
F. M. Soliman,
Heba M Zaki
Publication year - 2016
Publication title -
journal of advances in chemistry
Language(s) - English
Resource type - Journals
ISSN - 2321-807X
DOI - 10.24297/jac.v12i5.5180
Subject(s) - coumarin , chemistry , carrageenan , anti inflammatory , moiety , edema , pharmacology , cytokine , stereochemistry , biochemistry , organic chemistry , medicine , immunology
Starting from 6-amino-4-methyl-2H-chromen-2-one 1, a series of some new heterocyclic compounds (2-14) incorporating coumarin moiety was synthesized and assessed for their anti-inflammatory activity using the carrageenan-induced hind paw edema method. The tested coumarin derivatives reduce the edema volume and serum levels of the pro inflammatory cytokines, IL-6 and TNF-α, and have effects on promoting production of anti-inflammatory cytokine, IL-10.