Synthesis of some Heterocyclic compounds bearing Coumarin nucleus and their Anti-inflammatory activity | Zendy

Nadia T. A. Dawoud | Zendy; Nahed Abdel-Ghaffar | Zendy; Mona M Abdl-gali | Zendy; Fekria M. A. Soliman | Zendy; Heba Zaki | Zendy

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Synthesis of some Heterocyclic compounds bearing Coumarin nucleus and their Anti-inflammatory activity

Author(s) -

Nadia T. A. Dawoud,

Nahed Abdel-Ghaffar,

Mona M Abdl-gali,

Fekria M. A. Soliman,

Heba Zaki

Publication year - 2016

Publication title -

journal of advances in chemistry

Language(s) - English

Resource type - Journals

ISSN - 2321-807X

DOI - 10.24297/jac.v12i5.5180

Subject(s) - coumarin , chemistry , carrageenan , anti inflammatory , moiety , edema , pharmacology , cytokine , stereochemistry , biochemistry , organic chemistry , medicine , immunology

Starting from 6-amino-4-methyl-2H-chromen-2-one 1, a series of some new heterocyclic compounds (2-14) incorporating coumarin moiety was synthesized and assessed for their anti-inflammatory activity using the carrageenan-induced hind paw edema method. The tested coumarin derivatives reduce the edema volume and serum levels of the pro inflammatory cytokines, IL-6 and TNF-α, and have effects on promoting production of anti-inflammatory cytokine, IL-10.

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