Open AccessSynthesis, Characterization and Evaluation of Anti-inflammatory Activity of Novel Indoline Derivatives
Author(s) -
dhinesh kumar manoharan
Publication year - 2016
Publication title -
journal of advances in chemistry
Language(s) - English
Resource type - Journals
ISSN - 2321-807X
DOI - 10.24297/jac.v12i12.4826
Subject(s) - indoline , chemistry , carbon 13 nmr , ic50 , denaturation (fissile materials) , in vitro , stereochemistry , nuclear chemistry , combinatorial chemistry , biochemistry
Series of indoline derivatives were synthesized using N-(4-aminophenyl) indoline-1-carbothiamide as a precursor. The structures of synthesized compounds were confirmed by FT-IR, 1H-NMR, 13C-NMR and LC-MS. The in vitro anti-inflammatory activity of synthesized indoline derivatives were examined by standard anti-denaturation assay. The compounds 4a (IC50 = 62.2 µg/ml) and 4b (IC50 = 60.7 µg/ml) showed potent inhibition on protein denaturation. The compounds 5a (IC50 = 97.8 µg/ml) exhibits moderate inhibition on protein denaturation