Open AccessInvestigation of Hypoglycemic Effect 4-(2--Hydroxyethyl)phenol Compounds Is from Iraqi an Prosopis Juliflora Pods On Level of Glucose Blood of Alloxan - Induced Diabetes Rabbits
Author(s) -
Jamal Harbi Hussien Alsaadi,
Abbas Al-Maliki
Publication year - 2014
Publication title -
journal of advances in chemistry
Language(s) - English
Resource type - Journals
ISSN - 2321-807X
DOI - 10.24297/jac.v10i9.879
Subject(s) - alloxan , prosopis juliflora , phenol , diabetes mellitus , chemistry , saline , traditional medicine , chromatography , medicine , pharmacology , biology , endocrinology , botany , organic chemistry
Prosopis juliflora is herbal plant traditionally used in different countries to treat diabetes .In present study the chemicals of Prosopis juliflora pods were specified by GC-MS ,NMR ,IR and TLC techniques which identified the many chemicals family compounds .extraction percentage of 4-(2’-Hydroxyethyl)phenol compound was (2.532 % ) . Alloxan –induced diabetic rabbits were prepared in present study after injecting the experimental rabbit with three dose of alloxan (I.V).Hyperglycemic rabbits were divided to tow groups. First group was administration orally with 0.3 g/kg of Phenolic compound (treatment group)) and second group was administrated orally with normal saline (control group) . the lowest level of glucose was observed in alloxan –induced diabetic rabbits that administrated with phenolic compound and the significant decreasing was observed after 4hrs of administration at ( P<0.001). ). Its can be concluded from the current study the phenolic compound from Prosopis juliflora pods is very good for reduce glucose blood of hyperglycemic rabbits the 4-(2’-Hydroxyethyl)phenol compound isolated was purified and identified using TLC ,NMR ,GC-MS,IR techniques.Therefor this compound can be used safely to treat diabetes mellitus.