Open AccessAnti-herpetic activity exopolysaccharides produced by different species of lactic acid bacteria
Author(s) -
Krystyumenko,
L.O. Biliavska,
Yulia Pankivska,
Olga Povnitsa,
Olga Vasyliuk,
I.L. Garmasheva,
Svіtlana Zagorodnya
Publication year - 2019
Publication title -
journal of advances in biology
Language(s) - English
Resource type - Journals
ISSN - 2347-6893
DOI - 10.24297/jab.v12i0.8058
Subject(s) - bacteria , herpes simplex virus , virus , lactic acid , titer , microbiology and biotechnology , lactobacillus , biology , penetration (warfare) , viral replication , chemistry , virology , genetics , operations research , engineering
In the present work, it was shown that, in non-toxic concentrations, all EPSs which were isolated from lactic acid bacteria have significant anti-HSV-1 activity affecting various stages of the virus reproduction. It was demonstrated that the use of ESPs leads to the normalization of the life cycle of cells infected with the herpes simplex virus to the level of uninfected cells. It was found that EPS 26a produced by Lactobacillus sp. possesses multiple antiviral effects as it exhibits virucidal activity, blocks adsorption, penetration of the virus into cells and the release of viruses, and reduces the infectious titer of herpes simplex virus by 97-99%, indicating its considerable anti-herpetic activity.