Open AccessSirtuins in wound healing
Author(s) -
Akihiro Aioi
Publication year - 2019
Publication title -
trends in immunotherapy
Language(s) - English
Resource type - Journals
ISSN - 2573-5985
DOI - 10.24294/ti.v3.i2.122
Subject(s) - wound healing , inflammation , sirt6 , hemostasis , histone deacetylase , microbiology and biotechnology , biology , calorie restriction , sirtuin , histone , nad+ kinase , medicine , immunology , endocrinology , genetics , biochemistry , gene , enzyme
Sirtuins (SIRTs) are initially recognized as NAD+-dependent histone deacetylase. SIRTs attract attention for their role as calorie restriction-induced “longevity proteins” to be expected to extend human life span and to promote health. As advancing studies, SIRTs have been recognized as cell signaling regulators which contribute to anti-inflammation, cell differentiation and so on. Therefore, SIRTs are supposed to affect wound healing which is comprised highly orchestrated complex four phases: hemostasis, inflammation, tissue formation and tissue remodeling. This review highlights the roles of SIRTs in wound healing process and provides a foundation and impetus for future basic and clinical research.