Open AccessPEMETAAN EPITOP DAN APLIKASI KLINISNYA
Author(s) -
Jusak Nugraha
Publication year - 2018
Publication title -
indonesian journal of clinical pathology and medical laboratory
Language(s) - English
Resource type - Journals
ISSN - 2477-4685
DOI - 10.24293/ijcpml.v17i3.1168
Subject(s) - epitope , linear epitope , epitope mapping , recombinant dna , medicine , virology , mimotope , phage display , antibody , peptide vaccine , computational biology , biology , immunology , biochemistry , gene
Epitope mapping is one of the important findings in immunoIogy. The idea of systematic epitope mapping was first described byGeysen et al (Geysen et al., 1987a,b). This technic is further developed together with other important findings such as monoclonalantibody production, DNA recombinant, peptide synthesis and phage display of peptide or protein. The usage of this technic is to know theexact binding site of antigen with antibody or T cell receptor, and can be used as the basic information to design a vaccine or diagnostictools. The term epitope can be further classified as functional epitope, structural epitope, binding epitope, protective epitope, heavyinfection epitope, neutralization epitope etc. In this article will be reviewed topics about epitope: B and T cell epitope mapping technicsusing synthetic pin and its application.