PENENTUAN DEFISIENSI BESI ANEMIA PENYAKIT KRONIS MENGGUNAKAN PERAN INDEKS sTfR-F

Background: The highest prevalence of nutrition problem due to nutrition deciency is iron deciency. Chronic disease anemia often occurs coincide with iron deciency and both show of low iron serum appearance. Difculty occurs when iron deciency determined in chronic disease anemia by routine parameters. Bone marrow stainning can indicate iron store, but it is invasive. Therefore it needs another more practical parameter that has higher diagnostic value. Objective: To know the more practical parameter that can determine iron deciency in chronic disease anemia Discussion: Ferritin serum indicates iron store in the body, whereas transferin receptor indicates functional of iron uptake in the erythrocyte. Changes of ferritin level due to inammation process are varies. Recent evidence shows different changes of transferin receptor between iron deciency anemia and those in chronic disease anemia. In chronic disease anemia, receptor transferin level increase but not as high as in those who suffer from pure iron deciency anemia. Studies on groups of iron deciency anemia, iron deciency with acute inammation, chronic disease anemia and healthy control population showed signicance differences of receptor transferin among them. sTrF-R index is an index derived from the calculation of transferin receptor level divided by logarithmic of the ferritin level. The usage of sTfR-F index indicates more signicance difference as compared to transferin receptor. Its sensitivity and specicity increase when it is applied to diagnose iron deciency in elderly group. Conclusions: sTfR-F index is more sensitive and specific for the determination of iron deficiency in chronic disease anemia