Open AccessA case report of pilocytic astrocytoma of the brainstem
Author(s) -
А. А. Меришавян,
Ludmila Papusha,
Э. Ф. Валиахметова,
Alexander Druy,
Л. А. Ясько,
В. В. Бриллиантова,
А. В. Артемов,
А. И. Карачунский
Publication year - 2020
Publication title -
voprosy gematologii/onkologii i immunopatologii v pediatrii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.108
H-Index - 3
eISSN - 2414-9314
pISSN - 1726-1708
DOI - 10.24287/1726-1708-2020-19-4-120-124
Subject(s) - brainstem , pilocytic astrocytoma , medicine , biopsy , astrocytoma , disease , neuroimaging , pathology , stereotactic biopsy , radiology , pediatrics , glioma , psychiatry , cancer research
Low-grade gliomas (LGGs) of the brainstem are a rare nosological group among brain tumours in children. In most cases, radical resection of the tumours localized in the brainstem is impossible due to the high risk of postoperative neurological complications. Presently, there are no uniform approaches to the management of patients with residual tumours of the brainstem; furthermore, current LGG treatment protocols disregard molecular and genetic features of the tumour. In our article we describe the case of the patient with LGG of the brainstem after the performed biopsy. Despite the large volume of the tumour, we decided to follow the patient over time due to the following factors: verification of the “pilocytic astrocytoma” histological diagnosis, detection of the KIAA1549-BRAF chimeric transcript (a marker of a favourable prognosis), as well as the absence of neurological deficit. According to the neuroimaging data, the child has stable disease for a long period of time. The patients' parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.