Open AccessBlood coagulation in the 21st century: existing knowledge, current strategies for treatment and perspective
Author(s) -
Н. А. Подоплелова,
В. Б. Сулимов,
Anna Tashchilova,
İvan Ilin,
Mikhail A. Panteleev,
И. В. Леденева,
Х. С. Шихалиев
Publication year - 2020
Publication title -
voprosy gematologii/onkologii i immunopatologii v pediatrii
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.108
H-Index - 3
eISSN - 2414-9314
pISSN - 1726-1708
DOI - 10.24287/1726-1708-2020-19-1-139-157
Subject(s) - hemostasis , coagulation , blood clotting , intensive care medicine , thrombosis , medicine , clotting factor , perspective (graphical) , computer science , surgery , artificial intelligence
Disorders in the blood coagulation system are the leading cause of death and disability in the modern world. So the search for new drugs that can prevent pathological thrombosis, while not affecting normal hemostasis, becomes more relevant than ever. Recent studies has been a revolution in the understanding of the principles of work and the regulation of blood coagulation. In addition, new, more effective approaches to drug development have now appeared. For example computer simulation methods that can significantly reduce the time and resources spent on the search for new candidate molecules. In the review, the blood clotting system, the molekular mechanisms of thrombosis, the role of blood coagulation factors Xa and XIa, and the urgency of developing new inhibitors of these targets are shown, and the most interesting inhibitors of factors Xa and XIa are presented.