Open Access一种用于检测恶性疟原虫青蒿素抗性的新型表型检测方法-环状体阶段生存测定法(RSA)及其改进的综述
Author(s) -
张捷,
Jie Zhang,
冯国华,
邹春燕,
苏品璨,
刘怀鄂,
杨照青,
Guo-Hua Feng,
Chunyan Zou,
Peng Su,
Huaie Liu,
Yang Zhou
Publication year - 2017
Publication title -
zoological research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 19
ISSN - 2095-8137
DOI - 10.24272/j.issn.2095-8137.2017.075
Subject(s) - artemisinin , plasmodium falciparum , biology , malaria , medicine , pharmacology , immunology
Artemisinin resistance in Plasmodium falciparum threatens the remarkable efficacy of artemisinin-based combination therapies worldwide. Thus, greater insight into the resistance mechanism using monitoring tools is essential. The ring-stage survival assay is used for phenotyping artemisinin-resistance or decreased artemisinin sensitivity. Here, we review the progress of this measurement assay and explore its limitations and potential applications.