Open AccessPotential of Modified Cassava Starch as a Tablet Binder in Direct Compression Method
Author(s) -
Wira Noviana Suhery,
Anita Lukman,
Afriyanti Afriyanti
Publication year - 2021
Publication title -
ad-dawaa' journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
eISSN - 2654-6973
pISSN - 2654-7392
DOI - 10.24252/djps.v4i2.25212
Subject(s) - friability , starch , modified starch , materials science , food science , chemistry , mathematics , composite material , polymer , ethyl cellulose
Research on the potential of modified cassava starch as a binder for the direct compression method has been carried out. The use of modified cassava starch as a binder using six formulas with the drug model ibuprofen. Variations in the concentration of modified cassava starch were modified cassava starch 48 and modified cassava starch 72 were 15%, 17.5%, and 20%, respectively. The formula with a modified starch 72 concentration (15%) is the best formula that produced optimal tablets. The value of hardness was 5.3 kg/cm2, friability of 0.90%, and disintegration time of 2.06 minutes which are the main parameters of the binder