Open AccessCorrelation of Fischer’s Ratio with Liver Fibrosis in Naive Chronic Hepatitis B Patients without Comorbidities
Author(s) -
Mohammad Rilwanu Rafsanjani,
Triyanta Yuli Pramana,
- Arifin
Publication year - 2021
Publication title -
asian journal of pharmacy, nursing and medical sciences
Language(s) - English
Resource type - Journals
ISSN - 2321-3639
DOI - 10.24203/ajpnms.v9i6.6786
Subject(s) - medicine , gastroenterology , transient elastography , fibrosis , chronic hepatitis , liver fibrosis , liver function tests , hepatitis b , correlation , chronic liver disease , cirrhosis , virus , immunology , mathematics , geometry
Hepatitis B virus infection is one of the most common health problems in the world. 20% Chronic hepatitis B can can change into liver fibrosis. The liver is the center of the body's Amino Acids metabolism. Amino acid changes can occur due to impaired liver function. Fisher's ratio (BCAA/AAA) has become one of the sign of liver fibrosis. This study wanted to find a relationship between Fischer Ratio values and liver fibrosis in naive chronic hepatitis B patients without comorbidities.Method:The research was conducted from October 2020-May 2021 at DR. Moewardi Hospital, Surakarta, Indonesia. Subjects were naive chronic hepatitis B patients without comorbidities with a minimum age of 30 years. The study used a cross-sectional method. Fischer Ratio values were assessed by spectrophotometry and liver fibrosis was assessed by transient elastography (fibroscan). A correlation test was conducted to determine the relationship between variables.Result:20 patients were included in the study. The average age of the research subjects was 47 ± 10 years. The average Fisher's ratio value was 2.83 ± 1.16 and the average fibroscan value was 17.31 ± 18.50 kPa. Ratio Fischer had a correlation with liver fibrosis with r= - 0.571 (p=0.004).Conclusions:Ratio Fischer has a negative correlation with liver fibrosis in naive chronic hepatitis B patients without comorbidities.