Prevalence of Occult Hepatitis B in Patients with Lupus Nephritis and Glomerulopathy Referred to Shahid Sadoughi Hospital in Yazd, Iran

Background: The conventional method for testing Hepatitis B (HBsAg) can be not detected  occult Hepatitis B in patients. No diagnosis of hepatitis B in patients with lupus nephritis and glomerulopathy treated with Immunosuppressive drugs, can be clear Hepatitis B. Also, due to the possible role of occult Hepatitis B in the lack of a complete response to treatment and continue proteinuria Assess the prevalence of occult Hepatitis B in these patients is important.in this study we decided to the survey Prevalence of occult hepatitis B in patients with lupus nephritis and glomerulopathy referred to SHAHID SADOUGHI Hospital in Yazd.Methods: This study was a descriptive-cross sectional study. A total of 112 patients with lupus nephritis and glomerulopathy referred to internal department, nephrology and rheumatology clinic of SHAHID SADOUGHI Hospital in five-year period studied. HBsAg, HBsAb was measured in patients and those with HBsAg positive and HBsAg negative HBV-DNA was measured. Demographic was collected in the questionnaire that already provided. The collected data were entered into SPSS version 20, using statistical tests were analyzed.Result: The results showed that the mean age of participants was 40.84 ± 15.11 years. From 112 patients participated in the study,49 patients (43.8%) were men and63 patients (56.2%) were female. Also from 112 patients,97 patients (86.6%) had primary glomerulopathy and 15 patients (13.4%) had lupus nephritis. The prevalence of occult hepatitis B was 3.0% in patients with primary glomerulopathy and 13.3% in lupus nephritis patients. There was a significant relationship between the frequency of HBc-Ab and the mean age of patients with type of disease (P-value <0.05).Conclusion: The prevalence of occult hepatitis B in patients with lupus nephritis was greater than the prevalence in pateints with gleumeronephritis.