Open AccessReview: Hepatoprotector Compounds in Plant Extracts
Author(s) -
Dichy Nuryadin Zain,
Riezki Amalia,
Jutti Levita
Publication year - 2019
Publication title -
indonesian journal of applied sciences (ijas)
Language(s) - English
Resource type - Journals
eISSN - 2581-1991
pISSN - 2089-9203
DOI - 10.24198/ijas.v8i1.16967
Subject(s) - hepatotoxin , chemistry , radical , traditional medicine , antioxidant , crocus sativus , botany , biochemistry , biology , organic chemistry , medicine , toxicity
Many plants have been reported to possess hepatoprotective activity. The mechanism has not yet been revealed, but it was predicted due to the antioxidants that could prevent the formation of free radicals produced by hepatotoxins. Of the 30 plants studied, Crocus sativus gave the largest hepatoprotector activity at a dose of 20 mg / kg, followed by Uncaria gambier Roxb. with a dose of 30 mg / kg and Melastoma malabathricum Leaf at a dose of 50 mg / kg. Keywords: Liver, CYP450, antioxidant, free radicals