Open AccessAssessment of Adenosine deaminase specific activity in serum and saliva of patients with chronic gingivitis
Author(s) -
Hazema Mossa Khalil,
Zahraa Hussein M. Kadri,
Hadeel Khlil Rahman
Publication year - 2014
Publication title -
maǧallaẗ markaz buḥūṯ al-taqniyyaẗ al-aḥyāʾiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2708-1370
pISSN - 1815-1140
DOI - 10.24126/jobrc.2014.8.2.327
Subject(s) - saliva , adenosine deaminase , inosine , gingivitis , biomarker , medicine , immune system , adenosine , deamination , enzyme assay , immunology , enzyme , gastroenterology , dentistry , chemistry , biochemistry
Adenosine deaminase (ADA) is an enzyme that catalyzes the deamination of adenosine to inosine. The enzyme is widely distributed in human tissues and work as a marker of cellular immunity, and its activity is found to be elevated in those diseases in which there is a cell-mediated immune response. The aim of this study was to explore the usefulness of ADA specific activity in serum and saliva as a biomarker of chronic gingivitis (CG). Thirty CG patients and 15 CG-free controls were enrolled in the study, and they were attendant of the Dental Clinic at the College of Dentistry Medicine (University of Baghdad) during the period January-March 2013. The results demonstrated that the ADA mean specific activity was significantly (P ≤ 0.001) increased in serum (17.58 ± 0.81 vs. 0.75 ± 0.03 U/mg protein) and saliva (85.43 ± 2.43 vs. 0.11 ± 0.03 U/mg protein) of CG patients as compared with controls. Accordingly, it is possible to conclude that ADA specific activity might be a good biomarker for CG, especially in saliva, and can reflect inflammatory and destruction processes in the periodontal tissue.