Open AccessEffect of Ethanolic Olive leaf and its Callus Ethanol Extracts in Alloxan- induced Diabetic mice (Blood glucose and lipid profiles)
Author(s) -
Sally Badawi,
Saleh Ahmed,
Nabeel Al ani
Publication year - 2013
Publication title -
maǧallaẗ markaz buḥūṯ al-taqniyyaẗ al-aḥyāʾiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2708-1370
pISSN - 1815-1140
DOI - 10.24126/jobrc.2013.7.2.268
Subject(s) - alloxan , callus , very low density lipoprotein , lipid profile , chemistry , diabetes mellitus , endocrinology , ethanol , medicine , insulin , intraperitoneal injection , blood lipids , low density lipoprotein , cholesterol , lipoprotein , high density lipoprotein , biochemistry , biology , botany
This study was designed to test the lipid-lowering and antidiabetic activities of olive leaf and its callus extract. Diabetes in mice was induced by intraperitoneal injections of alloxan. The serum glucose and serum lipid were examined. Diabetic mice showed hypeglycemia, hypelipidemia. The administration, for 2 weeks of olive leaf and its callus extracts significantly decreased the Total cholesterol (TC). Triglycerides (TG). Low density lipoprotein (LDL), very low density lipoprotein (VLDL). Both types of olive extracts had significant hypoglycemic effects on blood glucose levels in diabetic mice. This hypoglycemic effect was as potent as the hypoglycemic effect of insulin. However, the callus extract was more potent than the leaves extracts and most potent than insulin in causing a significant decrease in LDL, VLDL, TC, TG and in antidiabetic effects.