Open AccessImmunomodulation of mice blood cells following treatment with free extract of Lactobacillus acidophilus cell
Author(s) -
Ebtehal H. Al-Naimy,
Ruqaya M. Al-Ezy,
Maysaa Ch. Al-Yas,
Muthanna A. S. Al Mahdawii
Publication year - 2010
Publication title -
maǧallaẗ markaz buḥūṯ al-taqniyyaẗ al-aḥyāʾiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2708-1370
pISSN - 1815-1140
DOI - 10.24126/jobrc.2010.4.2.134
Subject(s) - lactobacillus acidophilus , immune system , basophil , monocyte , immunology , lymphocyte , cell counting , biology , cell , microbiology and biotechnology , medicine , probiotic , bacteria , antibody , biochemistry , immunoglobulin e , genetics , cell cycle
A study aimed to examine immunomodulatory effect of concentrated cell free filtrate (CCF) of Lactobacillus acidophilus on immune system of mice by detecting the total and absolute counts of leucocytes. It was shown that CCF of Lactobacillus acidophilus caused a significant increase in total leucocyte count for all concentrations used in comparison with negative control. However, in absolute leucocyte counts the, CCF of L.acidophilus at doses (500 , 750) mg/kg caused a significant increased in lymphocyte, neutrophil and monocyte counts, while there was no significant differences in eosinophils and basophil cells number of mice treated with bacterial filtrate. The interaction study showed that the post-treatment with CCF of L. acidophilus caused a significant increase in total leucocytes count and absolute counts of all types of leucocyte cells except basophils and esinophils which showed no significant differences in comparison with pre-treatment