Open Accessتاثير المبيد Oxamyl في الوراثة الخلوية للخلايا اللمفاوية للدم المحيطي في الانسان
Author(s) -
Basheer I . Azawei,
Zahra M . Al-Khafaji,
Nahi Y. Yassein
Publication year - 2009
Publication title -
maǧallaẗ markaz buḥūṯ al-taqniyyaẗ al-aḥyāʾiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2708-1370
pISSN - 1815-1140
DOI - 10.24126/jobrc.2009.3.2.61
Subject(s) - micronucleus test , mitotic index , dicentric chromosome , micronucleus , chemistry , oxamyl , significant difference , zoology , medicine , andrology , biology , microbiology and biotechnology , mitosis , chromosome , pesticide , toxicity , genetics , biochemistry , karyotype , agronomy , gene
The effect of of carbamate pesticides (Oxamyl) on some parameters of cytogenetics of human peripheral blood lymphocytes was studied. These parameters were induction of chromosomal aberrations (CAs) and it's types; and formation of Micronuclei (Mn); in addition to estimating the mitotic index (MI) of cultured cells. The concentrations used were (0.1, 0.5, 5, 25, 50) × 10 -5 M which were added to lymphocyte cultures. Results indicated that the concentrations induced the CAs as the concentrations increased with positive correlation coefficient (r = + 0.904). Abnormalities in the control treatment were mainly as chromosomal breaks , these increased to 2 , 4 , 4 , 10 , 18 respectively and were with significant differences compared to control treatment (P 0.01), but started to decline at concentrations 5, 25, 50 × 10 -5 M and the values were 1.77, 1.5, 1.33 respectively compared to control treatment (2.5) with significant difference (P<0.01).