Open AccessUsing Lactobacillus as Probiotic to Inhibit Growth and Adhesion of Proteus mirabilis Causing Urinary Tract Infection
Author(s) -
Abdul Wahed Baker,
Ghydaa H. Aljeboury
Publication year - 2008
Publication title -
maǧallaẗ markaz buḥūṯ al-taqniyyaẗ al-aḥyāʾiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2708-1370
pISSN - 1815-1140
DOI - 10.24126/jobrc.2008.2.1.21
Subject(s) - proteus mirabilis , probiotic , microbiology and biotechnology , bacteria , proteus , pathogenic bacteria , adhesion , antibiotics , urinary system , lactobacillus , biology , chemistry , escherichia coli , pseudomonas aeruginosa , biochemistry , genetics , organic chemistry , gene , endocrinology
The aim of the study was to use lactic acid bacteria (LAB), as probiotic, to treat growth and adhesion property of Proteus mirabilis isolated from patients suffering from urinary tract infection (UTI). For this purpose, one P. mirabilis isolate (P.M.9) was selected out of 9 isolates obtained from 150 urine specimens. Due to its resistance to 11 antibiotics tested, this isolate was treated with three-fold concentrated filtrates of two lactobacillus isolates (as probiotic). Results after treatment, showed that the filtrates exhibited significant inhibitory effect against the pathogenic P.M.9 and its adhesion property especially when only an average of 3-10 bacteria /cell were adhered to each epithelial cell compared to 44-55 bacteria/cell.