Open AccessMicroalbuminuria besides to urinary enzymatic protein levels increase in Diabetic kidney disease with type II diabetics
Author(s) -
Osama F Mosa,
Mahmoud Rizk,
Abdel Ghaffar M. Ahmed
Publication year - 2018
Publication title -
sanamed
Language(s) - English
Resource type - Journals
eISSN - 2217-8171
pISSN - 1452-662X
DOI - 10.24125/sanamed.v13i2.254
Subject(s) - microalbuminuria , medicine , diabetic nephropathy , endocrinology , alkaline phosphatase , kidney disease , urinary system , diabetes mellitus , kidney , type 2 diabetes , urine , gastroenterology , urology , enzyme , chemistry , biochemistry
Background: Diabetic kidney disease (DKD) is a time progressive problem, give rise in uncontrolled Diabetics increasing risks for chronic kidney disease (CKD) and/or end-stage renal disease (ESRD). The vulnerability to renal dysfunction manifested with sudden glomerular hypofiltration associated with micro-to macroalbuminuria passing to renal failure. So that, screening of specific enzymes shifts, or urinary albumin may predict onset diabetic nephropathy. Objective: The assessment of urinary alkaline phosphatase (ALP), alanine aminopeptidase (AAP), acid phosphatase (ACP) and microalbuminuria (MAU) for type II diabetic patients. Patients and Methods: In this study,120 type II diabetic patients were compared to 90 healthy volunteers of matched age and sex in Al-Leith General Hospital, Al-Leith Kidney Unit (AKU), Al-Leith, Makkah area, KSA in which random urine samples were collected for testing of MAU, ALP, AAP, ACP and Cr. Results: Mean values of measured biomarkers in patient group for MAU, ALP, AAP, ACP and Cr were 51.92 mg/I, 41.55 U/L, 20.17 U/L, 570.10 U/L and 2.92 mg/dl VS in control group were 12.59 mg/I, 8.84 U/L, 6.94 U/L, 385.87U/L and 1.07 mg/dl respectively. Additionally, there were statistically positive correlation between AAP with MAU and ALP; ACP with MAU, ALP and AAP; Cr level with MAU, ALP, AAP and ACP; on the other hand, there were positive significant correlation between duration of diabetes with all studied markers. Conclusion: Using of MAU in addition to other urinary enzymes could be beneficial non-invasive indicators for renal deterioration in type II diabetics.