Comparison between amblyopic and other non-amblyopic eyes in terms of macula and retinal nerve fiber layer thickness

Statement of Significance: The prospect of this study is that the macula thickness is reduced in amblyopic eyes and may be a potential diagnostic tool in the future screening of amblyopic eyes. We did the unilateral anisometropic amblyopic patient comparison between amblyopic and non-ambliopic eyes in terms of average macular thickness and average retinal nerve fiber layer thickness with the help of spectral optical coherens tomography. Material and Methods: The study included 74 over 6 year old patients with unilateral anisometropic amblyopia. Comparison between 74 amblyopic and 74 non-amblyopic eye in terms of average macular thickness and average retinal nerve fiber layer thickness, with the help of spectral optical coherens tomography (OPKO Instrumentations, Miami, FL). The difference between healthy and amblyopic eyes, mean macular thickness and retinal nerve fiber layer thickness were evaluated by Mann-Whitney U test. Results: The mean age of the patients was 9.46 ± 1.86 (7-14 years old) and 40 patients were female (54.05%), 34 patients were male (45.95%). Amblyopia group average macular thickness and mean retinal nerve fiber layer thickness respectively 235.31 ± 21.3 micron (m) and 100.96 ± 11.45 m while non-amblyopia group average macular thickness and mean retinal nerve fiber layer thickness respectively 258.59 ± 13.91 m and 103.68 ± 14.55 m. Although statistically significant difference (p = 0.001) was observed with Mann-Whit-ney U test in terms of macular thickness, while in terms of retinal nerve fiber layer the difference between two groups was not statistically significant (p = 0,34). Conclusions: Average macular thickness measurements taken with OCT device varies in anisometro-pic amblyopic eyes is an important concept for future studies.