Open AccessOPTIMASI SUHU DAN LAMA PEMANASAN TERHADAP HASIL SINTESIS SENYAWA BENZOILTIOUREA DENGAN METODE ASILASI
Author(s) -
Harry Santosa,
Dini Kesuma
Publication year - 2019
Publication title -
jurnal ilmiah sains dan teknologi
Language(s) - English
Resource type - Journals
ISSN - 0216-1540
DOI - 10.24123/jst.v1i3.2237
Subject(s) - chemistry , yield (engineering) , tetrahydrofuran , thiourea , nuclear chemistry , melting point , solvent , chromatography , materials science , organic chemistry , metallurgy
To find new compounds acting on central nervous system (CNS), this research has been done the synthesis of benzoylthiourea by acylating the thiourea with benzoyl chloride, using tetrahydrofuran as solvent. Reaction temperature were respectively done at 90oC, 100oC, 110oC and 120oC, and heating duration was respectively accomplished at 0.5 hours, 1.0 hours, 1.5 hours, 2.0 hours and 2.5 hours. This research was aimed at finding out optimal heating duration and temperature to obtain maximal percentage yield of benzoylthiourea synthesis. The highest percentage yield of 59.89% obtained in optimum temperature 100oC and 2.0 hours heating duration. The purity test of the synthesis product is shown by the single spot on the thin layer chromatogram (TLC) and narrow range of melting point. Based on the structure identification with UV and IR spectrophotometries, H-NMR spectrometries and Gas Chromatography- Mass Spectrometries (GC-MS), it was concluded that the structure of the synthesis product was accordance to the prediction.