Ligational Behavior of Synthesized New Hydrazones Towards Oxovanadium (IV) Complexes and Their Antituberculosis Aspects

The synthesis of some oxovanadium (IV) complexeswithbidentateligands(newsynthesized biologically active hydrazones) derived from 2-methyl-4-(N-cyanoethyl)-N-benzenesulphonyl-benzylidene-3-oxo-[N-(substituted-1-phenyl)propanamido] hydrazone were analyzed.The complexes prepared were of the type [VO.L2] (where L= different new synthesized hydrazones).The characterization of these newly synthesized hydrazones and their metal complexes were done by IR, 1H-NMR spectral studies and elemental analysis. The infrared data of these complexes revealed the bidentate nature of the ligands and coordination to imino nitrogen of the amido group and azomethinic-nitrogen atoms. The new products were synthesized and evaluated for anti-tuberculosis activity against Mycobacterium tuberculosis H37RVin L.J.medium. The biological screening data indicates that the metal chelates are more potent than the parent ligands.