Open AccessTwin study confirms virtually identical prenatal alcohol exposures can lead to markedly different fetal alcohol spectrum disorder outcomes-fetal genetics influences fetal vulnerability
Author(s) -
Susan J Astley Hemingway,
Julia M. Bledsoe,
Allison Brooks,
Julian K Davies,
Tracy Jirikowic,
Edwin S. Olson,
John C. Thorne
Publication year - 2018
Publication title -
advances in pediatric research
Language(s) - English
Resource type - Journals
ISSN - 2385-4529
DOI - 10.24105/apr.2019.5.23
Subject(s) - fetal alcohol spectrum disorder , fetus , sibling , fetal alcohol syndrome , medicine , dizygotic twin , twin study , dizygotic twins , obstetrics , pregnancy , pediatrics , genetics , psychology , biology , developmental psychology , heritability
Risk of fetal alcohol spectrum disorder (FASD) is not based solely on the timing and level of prenatal alcohol exposure (PAE). The effects of teratogens can be modified by genetic differences in fetal susceptibility and resistance. This is best illustrated in twins.