Open AccessCOMPARATIVE IN VITRO EVALUATION OF SOME COMMERCIAL BRANDS OF RAMIPRIL TABLETS MARKETED IN INDIA
Author(s) -
P D GOKULAN,
K L SENTHILKUMAR,
V VASANTHAN,
V SURESH,
. VENKATESHWARAN,
A KOMATHI,
K MANJUSHREE,
T THILAGAVATHI
Publication year - 2022
Publication title -
current research in pharmaceutical sciences
Language(s) - English
Resource type - Journals
ISSN - 2250-2688
DOI - 10.24092/crps.2022.120105
Subject(s) - friability , ramipril , dissolution testing , business , pharmacy , medicine , pharmacology , drug , family medicine , biopharmaceutics classification system , first pass effect , blood pressure , radiology
The availability of several brands of Ramipril tablets in Indian pharmacies now poses a generic replacement concern for doctors. The goal of this study was to evaluate and compare different brands of Ramipril manufactured by various Indian pharmaceutical businesses under various trade names in order to reduce health risks and ensure the safety of local residents. General quality assessments of these tablets, such as diameter, thickness, hardness, weight variation, friability, disintegration, and dissolution tests, were also carried out according to recognised protocols, with test results falling within the acceptable range. Active components were measured using an approved UV spectrophotometric technique. This type of research is useful for determining the idealness of commercial products. KEYWORDS: Ramipril, In vitro evaluation, Dissolution study, Disintegration test