Open AccessLevels of Apelin, Endoglin, and Transforming Growth Factor Beta 1 in Iraqi Women with Polycystic Ovary Syndrome
Author(s) -
Noor Ibrahim,
Wasnaa J. Mohammad,
Sanan T. Abdawahab
Publication year - 2020
Publication title -
cihan university-erbil scientific journal
Language(s) - English
Resource type - Journals
eISSN - 2707-6377
pISSN - 2519-6979
DOI - 10.24086/cuesj.v4n1y2020.pp21-25
Subject(s) - polycystic ovary , apelin , medicine , endocrinology , luteinizing hormone , insulin resistance , infertility , sex hormone binding globulin , prolactin , testosterone (patch) , follicular phase , follicle stimulating hormone , hormone , insulin , biology , androgen , receptor , pregnancy , genetics
Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility in women of reproductive age. The aim of the study was to determine the level of apelin, insulin resistance (IR), transforming growth factor beta 1 (TGF-β1), and endoglin in women with polycystic ovary syndrome. Fifty PCOS patients and 40 non-PCOS infertile patients were recruited. The fasting serum levels of folliclestimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), prolactin, fasting blood glucose, insulin, and apelin at the early follicular phase were measured. Levels of apelin, LH, LH/FSH, T, and fasting insulin, as well as homeostatic model assessment of IR (HOMA-IR) in PCOS patients, were significantly higher than in the control group. Correlation analysis showed that apelin level was positively correlated with body mass index and HOMA-IR. Apelin levels and TGF-β1 were significantly increased in PCOS patients while show decrease levels of endoglin.