Open AccessMetronomic chemotherapy for advanced diffuse hepatocellular carcinoma in a dog
Author(s) -
Paloma Silva,
Mayara de Souza,
Ellen Cavalcanti,
Victoria Fonseca,
Tatiany L. Silveira,
Mayra Cunha Flecher,
Geovanni Dantas Cassali,
R.S. Horta
Publication year - 2021
Publication title -
brazilian journal of veterinary pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.161
H-Index - 10
ISSN - 1983-0246
DOI - 10.24070/bjvp.1983-0246.v14i3p199-205
Subject(s) - medicine , histopathology , hepatocellular carcinoma , chemotherapy , histopathological examination , pathology , radiology
Primary liver tumors represent 0.6% to 1.3% of neoplasms in dogs. Hepatocellular carcinoma (HCC) is the most common liver tumor. It is divided into three morphological groups: massive, nodular and diffuse. The presumptive diagnosis is made through imaging tests, such as ultrasound, although confirmation is made by histopathology. Surgery remains the treatment of choice for massive tumors, but there is no standard treatment for nodular and diffuse forms. This study aimed to report a case of prolonged survival in a dog with diffuse HCC, treated with metronomic chemotherapy and palliative care including non-steroidal anti-inflammatory and low-dose naltrexone.