Open AccessThe flavonoid Licochalcone A induces tegumental damages in Schistosoma mansoni and impairs its oviposition in vitro
Author(s) -
Juliane Marques Felicissimo,
Danielle Gomes Marconato,
Nayara Braga Emídio,
Lara Soares Aleixo de Carvalho,
Lívia de Carvalho Fontes,
Flávia Fernanda Búbula Couto,
Neusa Araújo,
Eveline Gomes Vasconcelos,
Josué de Moraes,
Pedro Pintó,
A. S Ferreira Filho,
Priscila de Faria Pinto
Publication year - 2021
Publication title -
brazilian journal of veterinary pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.161
H-Index - 10
ISSN - 1983-0246
DOI - 10.24070/bjvp.1983-0246.v14i3p165-172
Subject(s) - schistosoma mansoni , in vivo , in vitro , biology , integument , pharmacology , andrology , toxicology , immunology , helminths , anatomy , schistosomiasis , biochemistry , medicine , microbiology and biotechnology
In this study, Licochalcone A (LicoA) was investigated in in vitro and in vivo assays. The survival of worms in culture, the pattern of oviposition, the count of intact tubers and the integrity of the coat were adopted in the in vitro tests. After the animals were perfused, the number of worms recovered, their location and the oogram study were the parameters analyzed to signal the existence of potential schistosomicidal activity in vivo. We observed reduction on the survival, integument integrity and reproduction of adult worms in vitro. Murine models did not show a significant difference in the parasitological parameters analyzed that indicate activity against the worms with an oral single dose of 25 mg/ kg of LicoA or two intraperitoneal injection of 50 mg/ kg LicoA. Nevertheless, it is too early to completely exclude the schistosomicide activity of LicoA, considering that the used dosage form could not provide a regular absorption of the drug.