Open AccessNon-functional neuroendocrine tumor with multisystemic metastasis in a cat
Author(s) -
Silvia A. F Baeta,
Douglas Marinho Abreu,
José Arthur C Sousa,
Ingrid S Farias,
Isael S Sá,
Silvana Maria M. S Silva,
Rogéria Serákides,
N.M. Ocarino
Publication year - 2021
Publication title -
brazilian journal of veterinary pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.161
H-Index - 10
ISSN - 1983-0246
DOI - 10.24070/bjvp.1983-0246.v14i2p117-122
Subject(s) - pathology , enolase , abdominal distension , medicine , immunohistochemistry , vimentin , neuroendocrine tumors , palpation , chromogranin a , radiology
An eight-year-old castrated female feline was referred for necropsy with a history of apathy, inappetence, abdominal distension, hypersensitivity to abdominal palpation, and evidence of abdominal neoplasms on ultrasound. Macroscopically, multifocal to coalescent, yellowish-white, firm and infiltrative nodules were observed on the surface of the parietal peritonium and in abdominal and thoracic organs. Microscopic characteristics of the neoplasm suggested a neuroendocrine origin, but did not allow a definitive diagnosis and determination of the origin. Immunohistochemistry revealed that neoplastic cells expressed vimentin, CD56, neuron specific enolase, and PGP 9.5 and were negative for biogenic amines and hormonal peptides. Based on anatomopathological and immunohistochemical findings, diagnosis of metastatic non-functional neuroendocrine tumor was confirmed.