Open AccessCutaneous non-epitheliotropic large T-cell lymphoma in an English Bulldog
Author(s) -
Halana Silva,
Rodrigo dos Santos Horta,
Bruna Voltolin de Sena,
Ana Carolina Brandão de Campos Fonseca Pinto,
Isabella Oliveira Almeida,
Júlia Rangel,
Tamara Daiane de Souza,
Mayra Cunha Flecher
Publication year - 2020
Publication title -
brazilian journal of veterinary pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.161
H-Index - 10
ISSN - 1983-0246
DOI - 10.24070/bjvp.1983-0246.v13i3p622-627
Subject(s) - lymphoma , dermis , medicine , cutaneous lymphoma , dermatology , pathology , mycosis fungoides
Cutaneous lymphoma is histologically classified in epitheliotropic and non-epitheliotropic, the first showing higher incidence in dogs, and the second, in cats. Non-epitheliotropic lymphoma presents lymphocyte aggregates in the dermis and subcutaneous tissue, however cutaneous annexes are not infiltrated. It is usually more aggressive than epitheliotropic lymphomas. The aim of this study was to report a case of non-epitheliotropic lymphoma in a 9-year-old, female, English Bulldog presented with non-ulcerated skin nodules adhered to deep tissues. Microscopic and immunophenotypic features supported the diagnosis of non-epitheliotropic large T-cell lymphoma. Treatment was initiated with modification of the LOPP protocol, replacing procarbazine by dacarbazine (600 mg/m²) for up to six cycles, with a three-month survival. In the 11th week of treatment, after recurrent episodes of vomiting and diarrhea, abdominal ultrasound was performed and revealed an infiltrative mass in the stomach's greater curvature topography, showing an expansive and accentuated increase in one week, when euthanasia was elected.