Open AccessCHANGES OF HORMONAL STATUS IN PREGNANT WOMEN WITH MISCARRIAGE IN EARLY GESTATION TERMS
Author(s) -
Iryna Kalinovska,
Iryna Kalinovska,
Petro Tokar
Publication year - 2020
Publication title -
neonatologìâ, hìrurgìâ ta perinatalʹna medicina
Language(s) - English
Resource type - Journals
eISSN - 2413-4260
pISSN - 2226-1230
DOI - 10.24061/2413-4260.x.4.38.2020.3
Subject(s) - miscarriage , pregnancy , human placental lactogen , gestation , placental lactogen , medicine , obstetrics , human chorionic gonadotropin , hormone , fetus , endocrinology , placenta , biology , genetics
. The article represents the results of the study of the placental hormone level during the early stages of gestation (5-20 weeks).
The aim of the study. To analyze the level of hormones of the fetoplacental complex in pregnant women with miscarriage, along with the dynamics of changes in these indicators. To evaluate the features of the hormonal status of women during law-risk pregnancy and miscarriage in history and the impact of these features on the functional state of the fetoplacental complex and the subsequent course of pregnancy.
Material and methods. We examined 30 somatically healthy women with a physiological course of pregnancy (the control group) and 30 pregnant women with a miscarriage in history (the main group).
Research results. It was found that the content of estradiol, chorionic gonadotropin and placental lactogen in the blood plasma of pregnant women of the main group was significantly lower during the entire gestational period compared to the control group. Estradiol levels in pregnant women with miscarriage were 4.2 times lower than in healthy pregnant women. Placental lactogen levels in the main group of pregnant women were 6.1 times lower, and chorionic gonadotropin - 3.7 times lower compared with the control group. There was also a significant backlog in the growth of hormone levels as the pregnancy progressed. In its turn it indicates the development of placental dysfunction in women with a miscarriage in history in the early stages of gestation.
Conclusions. As a result of the described changes there is a violation of the first wave of cytotrophoblast invasion and, as a consequence, incomplete gestational remodeling of segments of spiral arteries. The walls of blood vessels are not completely replaced by fibrinoid and the formed placental vessels do not provide a constant flow of arterial blood into the intervillous space. As a result, the uterine-placental area and the formed placenta are not ready to meet the needs of the developing fetus. In the future, this can lead to perinatal losses.