Forensic medical differential diagnosis of brain infarctions and hemorrhasis of traumatic genesis by mueller-matrix microscopy

. The aim of the work is to develop forensic criteria for differential diagnosis of traumatic hemorrhages (HTG), ischemic stroke (IS), and hemorrhages of nontraumatic genesis (HNG) formation by 3D Mueller-matrix microscopy of layers of azimuthal-invariant Mueller-matrix images of circular birefringence of histological sections of the brain. Material and methods. Native sections of brain taken from 110 corpses were used for the study in the case of: death from coronary heart disease - 20 (18.1%) native sections (group 1 - control); HTG - 30 (27.3%) sections (group 2), IIB - 30 (27.3%) sections (group 3), HNG - 30 (27.3%) sections (group 4). Measurement of the values of the distribution of coordinate parameters of polarization at the points of microscopic images was performed at the location of the standard Stokes polarimeter. Results. It is found that for each of the phase cross-sections of the field, the volume of distributions of complex amplitudes of sensitivity, specificity and balanced accuracy of statistical analysis of coordinate distributions of Mueller-matrix invariants of circular dichroism have maximum values for small phase shifts corresponding to their level. The maximum level of balanced accuracy of intergroup differentiation was revealed by calculating statistical moments of the 3rd and 4th order, which characterize the asymmetry and excess distributions of the Mueller-matrix invariants values of circular dichroism of histological sections of brain substance. Conclusions. Excellent balanced accuracy (95% - 96%) of differential diagnosis was achieved between the control group and all study groups, good accuracy (92% - 93%) between ischemic stroke and traumatic hemorrhage and satisfactory accuracy (85% - 86%) between traumatic and hemorrhagic strokes genesis.