Open AccessThe ultrastructure of capillaries endotheliocytes in muscular tissue after progenitor fetal liver cells transplantation in patients with chronic limb ischemia
Author(s) -
Р. В. Салютін,
S. S. Palianytsia,
O. V. Buslovych,
V. M. Bogolepov
Publication year - 2014
Publication title -
bukovinsʹkij medičnij vìsnik
Language(s) - English
Resource type - Journals
eISSN - 2413-0737
pISSN - 1684-7903
DOI - 10.24061/2413-0737.xviii.4.72.2014.209
Subject(s) - angiogenesis , revascularization , transplantation , progenitor cell , medicine , ischemia , stem cell , pathology , limb ischemia , liver transplantation , fetus , surgery , cardiology , biology , microbiology and biotechnology , myocardial infarction , pregnancy , genetics
The failure to perform reconstructive-restorative surgical interventions in distal arterial lesions, justifies the necessity to search and develop indirect methods of revascularization. One of the promising methods is the use of cell transplantation to activate the reparation and angiogenesis processes in the affected limb. The results of carried out preclinical studies with modeled ischemia in laboratory animals have shown significant activation of angiogenesis after transplantation of progenitor fetal liver stem cells. Consequently, the cell transplantation has been performed in patients with chronic limb ischemia. Using the electron microscopy techniques it was proved that at the ultrastructural level of endotheliocytes of capillaries in muscular tissue, cell transplantation contributes to substantial activation of angiogenesis in patients with chronic limb ischemia, and is a promising method of indirect revascularization.