Open AccessAnalysis of matrix metalloproteinases 2 and 9 expression rate by means of immunocytochemical diagnostic technique in patients with larynx cancer with regional metastases
Author(s) -
О. V. Kovtunenko,
S. M. Tymchuk,
B. V. Shportko
Publication year - 2014
Publication title -
bukovinsʹkij medičnij vìsnik
Language(s) - English
Resource type - Journals
eISSN - 2413-0737
pISSN - 1684-7903
DOI - 10.24061/2413-0737.xviii.4.72.2014.192
Subject(s) - larynx , matrix metalloproteinase , pathology , medicine , metastasis , cancer , laryngeal neoplasm , lymph , immunohistochemistry , matrix metalloproteinase 9 , biopsy , matrix (chemical analysis) , carcinoma , oncology , anatomy , chemistry , chromatography
In this study we investigated the expression levels of molecular markers of matrix metalloproteinase 2 and matrix metalloproteinase 9 in patients with larynx cancer with regional metastases. Cytological specimens were examined by means of immunocytochemical tecnique. The material was obtained by fine-needle aspiration biopsy. A relationship between the expression of the marker and the presence of metastases has been established. A link between the expression of molecular markers of matrix metalloproteinase 2 and matrix metalloproteinase 9 with metastasis to lymph nodes in a direct correlation has been proved which allows us to recommend the study of these markers as factors in the metastatic squamous cell carcinoma of the larynx in the regional lymph nodes in the neck.