Evaluation of local immunity and level of endogenous intoxication in patients with generalized periodontitis and concomitant chlamydia infection

It is defined the differences between the state of non-specific organism’s resistance and the level of endogenous intoxication in patients with generalized periodontitis (GP) and concomitant chlamydia infection. A thorough laboratory examination of 164 patients with GP of I and II stages of chronic course was conducted. To study the protective properties of periodontal tissue, nature of inflammatory response, level of phagocytosis we used the Yasinovskiy’s test (calculated migration of leukocytes in the oral cavity), we determined the concentration of lysozyme and secretory immunoglobulin A levels in oral fluid. In order to determine the overall redox activity of neutrophils we determined the rate of NBT test in peripheral blood and leukocytic intoxication index have been calculated from the results of complete blood count with the help of special formula. Taking into account the results of laboratory examination of patients, we found that the presence of chronic chlamydial infection damages the periodontal tissues greatly. More expressed lesion is confirmed by the increasing number of leukocytes emigration in 1.67 times, desquamation of epithelial cells - 1.25 times), decreased levels of lysozyme in 1.19 times and sIgA - to 1.22 times, the increasing of the level of endogenous intoxication, increasing of the total redox activity of neutrophils compared with those patients without comorbidity.