Open AccessThe influence of melatonin on the state of the glutathione system of the rat liver under the conditions of subacute alcoholic intoxication
Author(s) -
Н. В. Давыдова
Publication year - 2014
Publication title -
bukovinsʹkij medičnij vìsnik
Language(s) - English
Resource type - Journals
eISSN - 2413-0737
pISSN - 1684-7903
DOI - 10.24061/2413-0737.xviii.3.71.2014.135
Subject(s) - glutathione , melatonin , alcohol intoxication , glutathione peroxidase , endocrinology , alcohol , medicine , chemistry , pharmacology , biochemistry , enzyme , poison control , injury prevention , environmental health
The investigations of certain parameters of glutathione system in the liver of rats under the conditions of subacute alcohol intoxication revealed a decreased content of reduced glutathione and glutathione peroxidase activity as well as an activation of glutathione-S-transferase activity. An oral administration of “Vita-melatonin” against a background of subacute alcohol intoxication in a dose 5 mg/kg during 10 days prevented the changes of the parameters under study.