Open AccessEndothelial dysfunction and means of its correction in patients with hypertension and concomitant heart failure
Author(s) -
V. M. Miziuk
Publication year - 2014
Publication title -
bukovinsʹkij medičnij vìsnik
Language(s) - English
Resource type - Journals
eISSN - 2413-0737
pISSN - 1684-7903
DOI - 10.24061/2413-0737.xviii.2.70.2014.71
Subject(s) - heart failure , ivabradine , concomitant , cardiology , medicine , endothelial dysfunction , endothelin receptor , heart rate , blood pressure , receptor
The paper studies endothelial dysfunction in patients with arterial hypertension and concomitant heart failure using, besides basic therapy, selective inhibitor of if-channels of cardiac sinus node cells ivabradine. It was determined that patients with hypertension without heart failure are characterized by less pronounced changes of endothelial function. Additional use of ivabradin besides basic therapy induces a decrease of heart rate and promotes normalization of serum endothelin-1 level in patients with hypertension and heart failure.