Open AccessEffect of L-Carnitine on the Indices of endothelial Dysfunction and Inflammation Factors in Patients with Acute Myocardial Infarction Without the Q Wave
Author(s) -
Бахром Анисханович Аляви,
Sh. A. Iskhakov,
Ш. К. Муминов,
A. K. Tursunbaiev,
P. M. Tolipov,
M. G. Muhamedova
Publication year - 2014
Publication title -
bukovinsʹkij medičnij vìsnik
Language(s) - English
Resource type - Journals
eISSN - 2413-0737
pISSN - 1684-7903
DOI - 10.24061/2413-0737.xviii.1.69.2014.1
Subject(s) - medicine , carnitine , inflammation , endothelial dysfunction , myocardial infarction , brachial artery , cardiology , vasodilation , fibrinogen , endothelium , gastroenterology , blood pressure
Aim: To evaluate the influence of L-carnitine on inflammatory markers and indicators of endothelial function in patients with acute myocardial infarction without the Q wave.Materials and Methods: 40 patients with verified diagnosis of AMI without Q-wave. All the patients were matched by sex, age, weight and duration of the underlying disease. The patients were randomized into 2 groups. The first group ofpatients were on a standard basic therapy and additionally administered L- carnitine at a dose 5g/day, II- group consisted of patients who did not receive drugs with metabolic action. In dynamics (on the 1st and 10th day of the treatment) the parameters of endothelium vasodilation and markers of inflammation were evaluated.Results: On the background of the basic therapy in both groups an improvement in endothelial function resulting in an increase of brachial artery diameter was observed. However, the L- carnitine vasodilator effect was more pronounced and persistent as compared to group II. In the dynamics, CRP levels and plasma fibrinogen were more pronounced in the Ist group.