Open AccessThe influence of ademol on the indices of energy metabolism in the rat brain with a model of acute cerebral ischemia
Author(s) -
О. А. Khodakіvskyi
Publication year - 2013
Publication title -
bukovinsʹkij medičnij vìsnik
Language(s) - English
Resource type - Journals
eISSN - 2413-0737
pISSN - 1684-7903
DOI - 10.24061/2413-0737.xvii.2.66.2013.86
Subject(s) - ischemia , anesthesia , hydrochloride , medicine , adamantane , metabolism , energy metabolism , cerebral circulation , pharmacology , chemistry , biochemistry , organic chemistry
In experiments on rats with a model acute disorder of the cerebral circulation (bilateral carotid occlusion) it has been established that the introduction of a derivative adamantane 1-adamantiletiloxy-3-morpholino-2 propanol hydrochloride (under a conventional name ademol) in a dose of 2 mg/kg intraabdominally in the treatment mode (in an hour after insult and further 1 time per diem in every 24 hours during 4 days of cerebral ischemia) better than the cerebral protector cytikolin contributes to a decrease of disorders of carbohydrate and energy metabolism. A similar effect of ademol is one of the key mechanisms of its protective influence on ischemized neurons of the brain, pointing out to its perspective for the creation on its basis of a new cerebroprotective agent.