Open AccessThe level of the soluble molecule of adhesion of vascular cells-1 and L-selectin in patients with antiphospholipid syndrome: a relationship with the disease activity, endothelial dysfunction and atherosclerosis
Author(s) -
Yu. S. Seheda,
С. В. Шевчук
Publication year - 2013
Publication title -
bukovinsʹkij medičnij vìsnik
Language(s) - English
Resource type - Journals
eISSN - 2413-0737
pISSN - 1684-7903
DOI - 10.24061/2413-0737.xvii.2.66.2013.80
Subject(s) - antiphospholipid syndrome , medicine , endothelial dysfunction , concomitant , selectin , cell adhesion molecule , endothelium , endothelial activation , inflammation , disease , pathophysiology , endocrinology , cardiology , immunology , thrombosis
A significant increase of the indices of the molecule of adhesion of vascular cells-1 (sVCAM-1) and Lselectin was demonstrated in the course of the research in the blood of patients with antiphospholipid syndrome as compared with healthy persons. The levels of the substances under study were associated with the markers of the activity of an inflammatory process (ESR, TNF-α, IL-1, CRP), disturbances of the lipid metabolism, the presence of antiphospholipid antibodies and concomitant arterial hypertension, however, they practically did not depend on the age, gender, the duration of the disease, tobacco smoking, obesity and hypodynamia. Close correlations have also been established between an elevated concentration of sVCAM-1 and L-selectin and structural functional changes of the vascular endothelium, enabling to regard them to be circulating markers of an early development of atherosclerosis in patients with antiphospholipid syndrome.