Open AccessAn evaluation of the efficacy of therapeutic approaches to correcting the indices of the systems of coagulation and fibrinolysis, inflammation markers in patients with diabetes mellitus of type 2 with obesity
Author(s) -
K. F. Kehiopulo
Publication year - 2013
Publication title -
bukovinsʹkij medičnij vìsnik
Language(s) - English
Resource type - Journals
eISSN - 2413-0737
pISSN - 1684-7903
DOI - 10.24061/2413-0737.xvii.2.66.2013.64
Subject(s) - fibrinolysis , medicine , metformin , proinflammatory cytokine , diabetes mellitus , hemostasis , inflammation , type 2 diabetes mellitus , type 2 diabetes , obesity , gastroenterology , endocrinology
The paper investigates the state of the systems of coagulation and fibrinolysis, the level of proinflammatory markers in patients with diabetes mellitus (DM) of type 2 and obesity, in a correlation with risk factors of the development of cardiovascular diseases, as well as the efficacy of different therapeutic approaches to a correction of disturbed indicators of inflammation, hemostasis and fibrinolysis. It has been established that rational hypocaloric feeding, measures of a modification of the life style and the intake of metformin contribute to a statistically significant body weight loss, however, they are ineffective for correcting proinflammatory and procoagulant disorders. Combined therapy, including the intake of metformin and liraglutide is condurive to a more significal reduction of the body weight as compared with metformin monotherapy and contributes to an improvement of the parameters of lipid metabolism, a correction of proinflammatory disturbances and fibrinolytic insufficiency associated with DM.