Open AccessThe effect of melatonin on the catalase and the blood glutathione transferase activity of rats in case of intoxication with 2,4-dinitrophenol
Author(s) -
M. V. Dikal,
И. В. Мацёпа,
O. H. Cherniuh
Publication year - 2013
Publication title -
bukovinsʹkij medičnij vìsnik
Language(s) - English
Resource type - Journals
eISSN - 2413-0737
pISSN - 1684-7903
DOI - 10.24061/2413-0737.xvii.2.66.2013.61
Subject(s) - melatonin , catalase , glutathione , 2,4 dinitrophenol , chemistry , dinitrophenol , antioxidant , enzyme , blood serum , enzyme assay , medicine , blood concentration , endocrinology , pharmacology , biochemistry , biology
Changes of the blood antioxidant enzymes have been inverstigated on albino nonlinear male rats with toxic poisoning by 2,4-dinitrophenol. It has been established that the catalase activity in the rat blood increased against a background of the intoxication. At the same time, the glutathione transferase activity under the conditions of 2,4-dinitrophenol intoxication decreased as compared with the control. The introduction of exogenous melatonin resulted in a correction of the blood indices under study, approximating them to the control values.